Immunomodulators and biologics are being used more frequently and earlier in the course of treatment in a subset of patients with IBD. In addition, there has been a consensus that combination therapy is preferred, especially in high-risk patients with IBD, which increases the degree of immunosuppression. It is accepted that immunosuppressed patients, when exposed to infectious agents, can develop severe and, on rare occasions, life-threatening infections.
It is necessary for the patient to be educated regarding which vaccinations are necessary to prevent these rare but serious infectious complications associated with IBD therapy.
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